Exfoliated 2D transition-metal dichalcogenide (TMDCs)-based nanomaterials have captured a huge biomedical territory owing to their supreme physicochemical properties. However, the tedious and harsh chemical exfoliation of bulk MoS2 impacts its utility in the biological domain. The study introduces a facile and environmentally benign way of shape-tunable exfoliation of bulk MoS2 materials in an aqueous dispersion using designed self-assembled, tetrapeptide (Fmoc-HCKF–OH)-based nanostructures, generating hybrid MoS2-peptide nanosystems for both tumor-targeted [employing folic acid (FA) functionalization] and NIR-responsive delivery of anticancer siRNA/drug in glioma. Exfoliated MoS2-peptide NSs here prove to be an excellent photothermal agent by inducing a temperature elevation upto ∼51 °C upon 808 nm NIR absorption. Enhanced siRNA/Dox loading onto the 2D flat morphology of MoS2-peptide NSs resulted in ∼90% cancer cell death in C6 glioma cells under NIR exposure. The expression of the Galectin-1 oncogene was suppressed following the treatment. Thereafter, analysis in the C6 glioma syngeneic rat model demonstrated a significant reduction (>10 fold) in tumor volume with siRNA/Dox-loaded FA-MoS2-peptide NSs + NIR as compared to the phosphate buffer saline-treated control group. Further, in vivo biodistribution studies confirmed the higher targetability of FA-conjugated hybrid NSs. Taken together, our findings promote the utility of TMDC-based nanomaterials in conjecture with a biocompatible peptide scaffold as a trimodal chemo, gene, and phototherapeutic agent.
Recent Comments
Hello world!
A WordPress CommenterInterdum luctus accu samus habitant error nostra nostrum
Fletch SkinnerInterdum luctus accu samus habitant error nostra nostrum
Chauffina CarrDoloremque velit sapien labore eius lopren itna
Hans DownBloke cracking goal the full monty get stuffed mate posh.
Fletch Skinner